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Description
A Practical Approach to Quantitative Validation of Patient-Reported OutcomesCondition: BRAND NEW ISBN: 9781119376378 Year: 2022 Publisher: John Wiley & Sons Inc (US) Description: A Simulation Based Guide Using SAS In A Practical Approach to Quantitative Validation of Patient Reported Outcomes, two distinguished researchers, with 50 years of collective research experience and hundreds of publications on patient centered research, deliver a detailed and comprehensive exposition on the critical steps required for quantitative
Condition: BRAND NEWISBN: 9781119376378
Year: 2022
Publisher: John Wiley & Sons Inc (US)
Description:
A Simulation-Based Guide Using SAS
In A Practical Approach to Quantitative Validation of Patient-Reported Outcomes, two distinguished researchers, with 50 years of collective research experience and hundreds of publications on patient-centered research, deliver a detailed and comprehensive exposition on the critical steps required for quantitative validation of patient-reported outcomes (PROs). The book provides an incisive and instructional explanation and discussion on major aspects of psychometric validation methodology on PROs, especially relevant for medical applications sponsored by the pharmaceutical industry, where SAS is the primary software, and evaluated in regulatory and other healthcare environments.
Central topics include test-retest reliability, exploratory and confirmatory factor analyses, construct and criterion validity, responsiveness and sensitivity, interpretation of PRO scores and findings, and meaningful within-patient change and clinical important difference. The authors provide step-by-step guidance while walking readers through how to structure data prior to a PRO analysis and demonstrate how to implement analyses with simulated examples grounded in real-life scenarios.
Readers will also find:
A thorough introduction to patient-reported outcomes, including their definition, development, and psychometric validation
Comprehensive explorations of the validation workflow, including discussions of clinical trials as a data source for validation and the validation workflow for single and multi-item scales
In-depth discussions of key concepts related
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