E-Selectin/CD62E His Tag Protein, Cynomolgus
SKU: 73272109353

E-Selectin/CD62E His Tag Protein, Cynomolgus

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Description

E-Selectin/CD62E His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM 1, SELE, Selectin E, CD62 Antigen Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 Accession XP_005539998. 2 Concentration 95% by SDS PAGE & SEC HPLC Amino Acid Sequence Trp22 Pro556 with His Tag at the C Terminus

Product Specification


Species Cynomolgus
Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2
Accession XP_005539998.2
Concentration >95% by SDS-PAGE & SEC-HPLC
Amino Acid Sequence

Trp22-Pro556 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight

90-110kDa (Reducing)

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Liu ZJ, Tian R, An W, Zhuge Y, Li Y, Shao H, et al.. Identification ofE-selectin as a novel target for the regulation of post-natalneovascularization: implications for diabetic wound healing. Ann Surg. (2010)252:625–34.

Background

E-Selectin, officially known as Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) or CD62E, is a member of the Selectin family of cell surface glycoproteins with a molecular weight ranging from 107 to 115 kDa. This cell adhesion molecule plays a pivotal role in inflammation and neovascularization, particularly in wound healing and ischemic areas.
Upon tissue injury, the release of cytokines and chemokines, such as stromal cell-derived factor 1α (SDF-1α), triggers the local expression of membrane-bound E-Selectin on endothelial cells. Concurrently, it induces the expression of systemic reciprocal E-Selectin ligands on endothelial progenitor cells (EPCs) within the bone marrow, mediated by the C-X-C motif chemokine receptor 4 (CXCR4).
E-Selectin is transiently expressed on vascular endothelial cells in response to cytokines like IL-1 beta and TNF-alpha, peaking at 4 hours post-activation and decaying by 24 hours. This cell surface glycoprotein is integral to immune cell adhesion, specifically by interacting with SELPLG/PSGL1 on blood neutrophils, which facilitates their adhesion to cytokine-activated endothelium. E-Selectin may also contribute to capillary morphogenesis.
During inflammation, E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall by binding to E-Selectin ligands present on leukocytes. These initial interactions are dynamic, allowing leukocytes to roll along the vascular endothelium in the direction of blood flow. Subsequently, stronger interactions involving ICAM-1 and VCAM-1 lead to the extravasation of white blood cells through the blood vessel wall and into the extracellular matrix of surrounding tissues.

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SKU: 73272109353

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★★★★★ 5
these are amazing
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A must-have for teething puppies m safe, effective, and they actually love them These N-Bone types have a great Puppy Teething Rings have been a total lifesaver during the teething stage. My puppy spends a solid 15–20 minutes working on one, which helps soothe her gums and keeps her from chewing on furniture or shoes. They’re soft enough to be safe for developing teeth but firm enough to give her something satisfying to gnaw on. The chicken flavor clearly hits the spot—she gets excited every time I grab the bag. I also appreciate that they’re fully edible and made with ingredients like calcium and DHA to support growth. No rawhide, no weird plastic texture just a treat that’s designed for exactly what puppies need. They can get a little sticky if left out too long, so I recommend supervising and tossing any unfinished pieces. Other than that, these are easily one of the best teething products I’ve found. Worth every penny.
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Our new puppy kept biting everything-even us! Ten chew toys later and still biting. We bought these, and oh my!, what a difference. This keeps her occupied for l o n g periods of time and has settled her biting us down to almost never.
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Reviewed in the United States on May 9, 2026
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Shemeka Nisely
Omaha, US
★★★★★ 4
My Babies love them.
Flavor Name: Chicken - Regular, Size: 6 Count (Pack of 1), Flavor Name: Chicken - Regular, Size: 6 Count (Pack of 1)
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alicia
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