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Description
CALHM2 Recombinant Rabbit mAb (S-2671-146)Product Specification Host Rabbit Antigen CALHM2 Synonyms Calcium homeostasis modulator protein 2; Protein FAM26B; FAM26B Immunogen Synthetic Peptide Location Cell membrane Accession Q9HA72 Clone Number S 2671 146 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Mk Positive Sample U 2 OS, HeLa, U 87 MG, NIH 3T3, COS 7 Predicted Reactivity Bv Purification Protein A Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | CALHM2 |
| Synonyms | Calcium homeostasis modulator protein 2; Protein FAM26B; FAM26B |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q9HA72 |
| Clone Number | S-2671-146 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Mk |
| Positive Sample | U-2 OS, HeLa, U-87 MG, NIH/3T3, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Mk |
| IHC-P | 1:50 | Hu |
| ICC | 1:50 | Hu |
Background
CALHM2 (Calcium Homeostasis Modulator 2) is a 323-amino-acid, four-pass transmembrane protein that oligomerizes into an undecameric, voltage-gated channel which—in addition to its originally described roles in taste-bud ATP release and neuronal excitability—has recently been shown to reside in the inner mitochondrial membrane where it functions as a Ca²⁺-inhibited import channel that translocates the ECHA subunit of the mitochondrial trifunctional protein into the matrix to enable fatty-acid β-oxidation, cristae integrity and normal respiratory metabolism, thereby coupling ion-channel gating to cellular energy supply and implicating CALHM2 in metabolic and neuropsychiatric disorders.
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